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Managing Complications in PBC: How Do We Improve Patient Quality of Life?

In this comprehensive episode, Dr. Hetal Karsan, Chair of Medical Education for United Digestive, provides an in-depth guide to managing complications of Primary Biliary Cholangitis (PBC) and their impact on quality of life. He explains the autoimmune nature of PBC, its progression from inflammation to fibrosis and cirrhosis, and the importance of early diagnosis and treatment to prevent severe outcomes. Dr. Karsan details evidence-based therapeutic goals, including normalizing alkaline phosphatase and bilirubin levels, and outlines strategies for preventing and managing complications such as portal hypertension, variceal hemorrhage, ascites, hepatocellular carcinoma, osteoporosis, sarcopenia, fatigue, and pruritus. He offers practical clinical tips—from dietary guidance and exercise recommendations to vitamin supplementation and screening protocols—emphasizing the role of patient education, adherence, and emotional support. This episode is a valuable resource for clinicians and patients alike, offering clear strategies to preserve liver health, improve daily functioning, and enhance overall quality of life in PBC care.